Showing posts with label analyzed by Dr. William Matzner. Show all posts
Showing posts with label analyzed by Dr. William Matzner. Show all posts

QUALITY ADJUSTED LIFE YEARS (QALY)—THE FORGOTTEN DENOMINATOR


William Matzner, MD
Dr. William Matzner, Simi Valley, California
Author’s NOTE: The health promotion and wellness industry has often been asked to illustrate more quantitatively derived results if for no other reason than to justify budgetary increases based solely on the intuitive hypothesis that healthy people work better than unhealthy people. If better measured, wellness programming could stand to gain even broader support, larger budgets and a more prominent seat at the executive table. After all, who among those of us in the wellness business could argue against having a chief health officer in every corporation and organization. It really does make sense, but how many of those do you know? I, frankly, know none. 

Cost Effectiveness Analysis allows us to present highly credible (that’s credible to the actual financial leaders in organizations) economic evaluation that does, as a number of you have asked, take into account actual clinical costs along with more qualitative factors as well. That’s what separates CEA from ROI, the ability for a group of critical evaluators to agree on a range of measures, apply both real and assumed “value” to those measures and then calculate the Cost Effectiveness of programming.

My between the lines read of may articles addressing ROI in wellness is that a fear exists among practitioners that when measured critically, wellness programming will come up short on a purely economic scale. I believe otherwise, that when measured critically, those holding the corporate purse strings will see greater value in wellness spending than they currently, and often grudgingly, allow. Further, well developed Cost Effectiveness Analysis will allow wellness professionals to better allocate spending among more qualitatively valuable and more quantitatively valuable programming. 

Cost Effectiveness Analysis (CE Analysis) has been shown to be a useful tool in medicine to look at the true effectiveness of certain new (or even older) treatments. More recently I have written that it can prove to be a useful and flexible tool for looking at the effectiveness of various programs used in Corporate Health and Wellness programs. And as these corporate Health and Wellness programs become more common, CFOs want data to justify corporate spending for these programs.

At first glance, it appears that CE models developed for these programs involved simply looking at costs and decision tree analysis.  However, the denominator of the CE analysis takes into account the QUALITY of life, not just the prolongation of life delivered by the treatment.

The Quality Adjusted Life Year  (QALY) is a year of life that is lived in perfect health. It takes into account the length of time and the health related quality of life (HRQL). The latter is given a numeric value between 0 and 1. This HRQL can be estimated by a survey or can be calculated from life tables and other published studies.  The value of HRQL has its roots in expected utility theory, a well developed economic theory.

A specific example may help. Let us say that we are measuring a wellness program that reduces stress. At first, someone could say that the cost difference in such a program is small with respect to productivity, days lost etc. and that a decision tree will not point you towards implementing such a program. BUT, this doesn’t take into account the difference in effectiveness.  Let us say that a stress free life has a QALY of 1.0. However all the stress that one has at work may be severe enough to cause high blood pressure and release of adrenaline such that life would be less pleasurable and the QALY is reduced to 0.8. This would INCREASE the CE ratio by 20% (1/0.8). This leaves the non treatment side essentially costing 20% MORE, just because the quality is of life during stress is that much less.

The beauty and the flexibility of this approach is that we can turn subjective feelings and data about health and life into a NUMERIC value, and then use this to place in the denominator.

For example, there has been much recent discussion about stress in the workplace and how reducing stress may be an important mission for corporate health and wellness programs. A stress value or measure can easily be built into the model so that a stressful life has less QALY.  In this way the denominator becomes smaller and the CE ratio becomes larger (like adding a cost because the quality of life as a result is less).

The denominator in CE analysis, the QALY, can reflect pain and suffering as a result of problems like COPD or heart disease, the pain and debility of having surgery, or as we have alluded to, the mental and physical stress involved in a job. All these factors lead to a QALY less than one, making any treatment less effective once these subjective measures are taken into account. 

There seem to be two camps of those interested in corporate health and wellness—one that wishes to look at the objective benefits of programs, and another that wishes to emphasis overall well being and less stress. Using the CE approach, we can quantify the subjective benefits and then produce a calculation to show (via the numbers) real measurable benefits to making such programs better. This will give even more validity to the usefulness of Corporate Health and Wellness programs and hopefully to their acceptance by CFOs and their counterparts. 

About William L. Matzner, M.D., PhD, FACP 

Dr. William Matzner works in the area of healthcare economics consulting at Healthcare Analytics, LLC, in California. He graduated Phi Beta Kappa from Stanford University. He received his M.D. with Honors from Baylor College of Medicine. In 1988, he was the Solomon Scholar for Resident Research at Cedar Sinai Medical Center. Dr. Matzner subsequently was awarded a PhD in Neuro Economics from Claremont Graduate University. He is board certified in Internal Medicine and Palliative Medicine. He has researched and published extensively on the issue of reproduction and immunology in medical literature. He has been in private practice since 1989, specializing in Reproductive Immunology and Internal medicine. 

Consulting Website: https://healthcareanalytics.biz 
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William Matzner, MD (Simi Valley, California), has been practicing medicine since 1989, Internal Medicine and Reproductive Immunology. M.D. with Honors from Baylor College of Medicine.

Miscarriages can be prevented: Overview by Dr. William Matzner

WIlliam Matzner, MD, Simi Valley, CA
William Matzner, MD., Simi Valley, CA

Miscarriages can be prevented: Overview by Dr. William Matzner


Dr. William Matzner provides an overview on preventing miscarriage. 

An unexpected miscarriage can shatter dreams. Two more can be devastating. But now there is hope, and a solution. One in every 200 couples are too genetically similar to achieve successful pregnancy. And usually, they don't know it. That's why early detection is vital. Without intervention, the painful pattern of miscarriage occurs again and again. 


Introduction 

One in two hundred couples will experience two or more consecutive miscarriages. There are five reasons for miscarriage which have been identified: (1) Infection; (2) Anatomy abnormal; (3) Progesterone level low; (4) Chromosome abnormal; (5) Immune mechanisms.  There may also be unknown or undiagnosed reasons and some women have multiple reasons for miscarriages.  Your obstetrician will test for most other causes of pregnancy loss. 

Immune Systems 

Advances in immunology, the study of the body's defense systems, enable us to understand how during pregnancy, the mother's immune system is altered so that the fetus is not rejected by her body and allows the fetus to grow. 

The immune system is comprised of white blood cells, also known as leukocytes, which make a variety of antibodies . Some of the antibodies protect us and others are harmful to our bodies. Some of the antibodies that are important to the reproductive system are: Blocking (protective) antibodies, Antiphospholipid antibodies, and Antinuclear antibodies.  

When the immune system is the cause of miscarriage, the chances of mother having a successful pregnancy without treatment after 3 miscarriages is 30%, after 4 miscarriages 25%, and after 5 miscarriages 5%. With proper treatment, overall success is 80%!

Blocking Antibodies 

Early in pregnancy, the mother's immune system receives signals from the tiny fetus. Many of the signals are hormonal, but others come directly from genetic messages that the father has contributed. Some of the messages involve the tissue type, also known as the human leukocyte antigens (HLA) are the white blood cell (leukocyte) type. HLA are expressed on white blood cells. They are unique to each individual and allow the body to identify anything foreign to it such as infections, cancers, transplanted organs and fetuses. One half of the fetus's HLA type is contributed by mother and the other half by father. When a woman becomes pregnant, her body's immune system usually recognizes the father's HLA as different from her own, and the white blood cells in her uterus produce protective, blocking antibodies. These antibodies coat the baby's cells and protect the fetus from mother's killer cells (figure 1). 


If father's HLA is too similar to mother's, her cells may not recognize differences that are vital to the production of blocking antibodies. 


Women who have successful pregnancies and have no history of miscarriages normally, have high levels of blocking antibodies even in the non pregnant state vs women who miscarry and whose levels tend to be low even when pregnant.

Through HLA tissue typing we can identify couples who look too much "alike" In addition we can measure the ability of a couple's cells to respond to each other i.e. level of blocking antibodies, using sophisticated equipment which combine computers and laser (cell flow cytometry).

Treatment involves immunizing mother with concentrates of father's white blood cells so that the HLA signal is amplified. When blocking levels are elevated, prior to conception, the rate of successful term pregnancy is approximately 80%.  


The risk associated with white blood cell immunization is the possible transmission of infectious agents that the father's blood may be harboring. This can be avoided by testing his blood for any significant infections. Very uncommonly, there can be a local skin infection caused by bacteria on mother's own skin. This is easily treated.

Antiphospholipid Antibodies 


Phospholipid molecules are normal components of all cell membranes. Some also have glue like properties and allow cells to fuse (as you will see later). Antibodies to phospholipid molecules can, therefore, cause problems. Specifically, they can damage the inside of the blood vessel wall. This allows blood cells to stick to the site f the injury and cause blood clots (figure 3 & 4).
Some phospholipid molecules have adhesion properties i.e. glue like, and allow cells to fuse. The formation of the normal placenta involves the fusion of small cells called cytotrophoblasts into giant cells known as syncytiotro-phoblasts. The syncytiotrophoblasts play a key role in the regulation of nutrients going to the baby.

With each pregnancy loss, there is a 10% chance that the mother will develop an antibody to a phospholipid molecule (figure 2).

Most women with antiphospholipid antibodies are not sick. However, some have underlying autoimmune tendencies and should be appropriately evaluated. Women with underlying autoimmune diseases may have antiphospholipid antibodies even before they ever become pregnant. 

The treatment for antiphospholipid antibodies involves the use of low dose (baby) aspirin and a blood thinner called Heparin. Heparin is a very large molecule and is unable to cross the placenta. Aspirin is able to cross the placenta but the dose used is so small that the fetus is unaffected. The effectiveness of treatment is mush greater when the medication, if indicated, is started prior to conception and continued throughout the pregnancy. All medication, if indicated should be discussed with one's physician.

Antinuclear Antibodies 

The nucleus is the "brain" of the cell. It contains the information that regulates the function of the cell. Some people have antibodies to different nuclear components. What causes these antibodies to be made is currently under investigation but there appears to be a genetic susceptibility which may be reflected by the HLA tissue type (refer back to the section on blocking antibodies). 

The disease that we typically associate with antinuclear antibodies is Systemic Lupus Erythematosus (SLE). The miscarriage rate in SLE patients is much higher than that of the general population. Although most women who suffer recurrent miscarriages do not have clinical signs of SLE, many exhibit autoimmune phenomena which is similar to that seen in SLE patients. The placentas in these women are inflamed and weakened. 

The treatment for this problem is Prednisone, a corticosteroid, which suppresses the inflammatory process and stabilizes the cell. Prednisone does not pass through the placenta easily and is also broken down by enzymes in the placenta so that the fetus is exposed to only trace amounts. Additionally, the body produces the equivalent of 8 mg per day of this corticosteroid. When indicated, Prednisone should be started prior to conception. 

As the body is dynamic, antibody levels may change over time. This is illustrated in the figure below. Most people have no antinuclear antibodies all of the time (A,B). Many women who miscarry have borderline (C,D,E) or abnormal levels of antinuclear antibodies (F,G) (figure 5). 


Patients who develop new autoantibodies like antinuclear and antiphospholipid antibodies during pregnancy have a more guarded prognosis.


About William L. Matzner, M.D., PhD, FACP

Dr. William Matzner works in the area of healthcare economics consulting at Healthcare Analytics, LLC, in California. He graduated Phi Beta Kappa from Stanford University. He received his M.D. with Honors from Baylor College of Medicine. In 1988, he was the Solomon Scholar for Resident Research at Cedar Sinai Medical Center. Dr. Matzner subsequently was awarded a PhD in Neuro Economics from Claremont Graduate University. He is board certified in Internal Medicine and Palliative Medicine. He has researched and published extensively on the issue of reproduction and immunology in medical literature. He has been in private practice since 1989, specializing in Reproductive Immunology and Internal medicine.

Consulting Website: https://healthcareanalytics.biz
 
William Matzner, MD (Simi Valley, California), has been practicing medicine since 1989, Internal Medicine and Reproductive Immunology. M.D. with Honors from Baylor College of Medicine.

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